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The following data will then be extracted from the studies selected for inclusion using a data collection form, and recorded onto an Excel file: first author and year, study design, sample, intervention, type of measures, risk of bias assessment, and findings. Keep away from animals and children.This product has not been evaluated by the FDA. BMC Complement Altern Med 2017;17:130. Avoid prolonged use. For oral use after meals,4 capsules one time and thrice daily. SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. eCollection 2023. Bioinform Biol Insights. Holshue ML, DeBolt C, Lindquist S, et al. Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. It cannot be bought over-the-counter and not recommended for self-medication. to maintaining your privacy and will not share your personal information without The protocol will be disseminated in a peer-reviewed journal or presented at a relevant conference. In 2012, Prevention and Treatment Scheme of Traditional Chinese Medicine for Type B Influenza, issued by the State Administration of Traditional Chinese Medicine Chunyuan Liu, Xiaoqiang Li, Shaoqian Cai. Lianhua Qingwen Nevertheless, this systematic view should help further expand our understanding of Lianhua Qingwen combined with conventional antiviral Western Medicine treatments in COVID-19 and asymptomatic infection. Chinese Journal of nosocomial infection 2015;25:7279. Meanwhile, China also provides technical solutions through long-distance video exchanges to share treatment experience with Japan, South Korea, Italy, the United States, Iran, Singapore, and so on. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. Egger M, Davey Smith G, Schneider M, et al. This product should not be used in treatment of wind-cold. All data generated or analyzed during this study are included in this published article [and its supplementary information files]. Now. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. 6.Patients with fever over 38.5 , should go to the hospital. 2022 Aug 19;27(16):5292. doi: 10.3390/molecules27165292. [1]. LHQW is not approved by Singapore's HSA for the prevention and treatment of Covid-19. The proportion of severe patients admitted to covid-19 hospital is 15.7%, and the death rate of confirmed patients is 6.7%. Used for patterns of heat toxin assailing the lung in flu, manifested as fever, aversion to cold, muscle soreness, stuffy & runny nose, cough, headache, dry & sore throat, reddish tongue, yellow & greasy tongue coating. High-tech Demonstration Project of National Development and Reform Commission [1014] Data showed that novel coronavirus pneumonia was confirmed in China, and 74,187 people used Chinese medicine, accounting for 91.5%, of which 61,449 in Hubei Province used Chinese medicine, accounting for 90.6%. Zhao Liu, Fuzhong Shi, zhanqiu Yang. In 2019, Diagnosis and Treatment Scheme for Influenza (2019), issued by the National Health Commission PRISMA flow diagram of study and exclusion. Treatment of Sars-Cov-2: how far have we reached? [10]. The data extraction form will include the following items: Two reviewers/authors (ZXL and ZQ) will independently evaluate the quality of the included trials through assessing the risk of bias using the following tools, when appropriate: The following aspects of included trials will be assessed: sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, incomplete outcome data, and selective outcome reporting. Hypersensitivity to this product should stop usingallergic constitution with caution. In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. Consume daily after meal [3]. Effectiveness and Safety of Lianhua Qingwen Capsules for COVID-19: A Propensity-Score Matched Cohort Study. [29]. The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. Cao B, Wang Y, Wen D, et al. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsule are as follows: First, Your message has been successfully sent to your colleague. Les capsules Lianhua Qingwen sont les produits phares de Yiling Pharmaceutical pour le traitement de maladies spcifiques comme le rhume, la grippe et la COVID-19. Do not use this product if the property changed. WebChronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory response that is worsened by acute exacerbations. A park employee (R), seen wearing goggles and face mask, walks in a park in Beijing on March 14, 2020. Writing review & editing: Xiaolin Zhang. Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. Though no specific drug has been developed so far, emerging agents have been confirmed effective or potentially beneficial to restrain it. 12th-Five Year Plan Special Project of National Major New Drug Development Careers. Lianhua Qingwen How to take it to realize the maximal efficacy? Guyatt GH, Oxman AD, Vist GE, et al. All review authors critically reviewed, revised and approved the subsequent and final version of the protocol. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. Chinese Journal of viral diseases 2015;5:3524. Wu Yiling. cDepartment of lung diseases, the Third Clinical Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China. Methods: Also illustrates the potential biases within each of the included studies by presenting a risk of bias," table, graph, and summary. The abstracts of all studies will be independently screened by the review authors (XLZand QL). Clipboard, Search History, and several other advanced features are temporarily unavailable. [25]. The capsule is hugely popular and controversial as it traces its roots to a prescription that date back to classic medical texts written during the Han dynasty (206BC220AD), according to a report from the South China Morning Post. Second Prize of National Science and Technology Progress Awards Study on the effect of Lianhuaqingwen Granule on BALB /c mice infected with respiratory syncytial virus [J]. LHQW is approved by China'sNational TCM Administration for the treatment of mild covid-19. A statistically significant difference was identified between the Lianhua Qingwen group and the conventional drug group (OR=3.02, 95% CI=1.23 to 7.42, P=0.016). Pulmonary Imaging Improvement. Five studies reported improvement in pulmonary imaging. The Chinese embassy in the Philippines announced this on Wednesday, August 12, hailing it as an important progress in the entry of TCM products into the Philippine market.. National Health and Family Planning Commission of the people's Republic of China. Please try after some time. In 2009, Diagnosis and Treatment Scheme for Patients Infected with Type A H1N1 Influenza (2009), issued by the State Administration of traditional Chinese medicine a non-profit social enterprise that collaborates with other SE producers to build capacity in marketing, sales and operations. WHO Director-General's opening remarks at the media briefing on. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health. Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. [59] In the early stage, there is no specific medicine or vaccine; the intervention of Chinese traditional medicine compound Lianhua Qingwen and other traditional Chinese medicine have played an important role. Journal of Guangzhou University of traditional Chinese medicine, 2016 33:5404. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. 2023 Jan 12;17:11779322221149622. doi: 10.1177/11779322221149622. The Cochrane Collaboration, Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (Version 5.1.0). WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. A: Before treatment; B: After treatment. Medicine (Baltimore). This systemic review will evaluate the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19. > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). The Authors. Patients diagnosed with COVID-19 of all ages and racial groups will be included. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. World Healthy Organization. Study on the anti Staphylococcus aureus biofilm formation of Lianhuaqingwen capsule [J]. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. In this study, 100 participants were Effect of Lianhuaqingwen Capsule on lung index of mice infected with virus [J]. Dont take this medicine if the description has changed. Third, the capsule can shorten fever & coughting time. To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. Statistical heterogeneity will be assessed with the I2 statistic. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. Click to view Lianhua Qingwen detailed prescribing information Overdosage View Lianhua Qingwen Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. [23]. In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission your express consent. < 5 years: not recommended because it may be difficult for young children to swallow capsules. Chest radiographs. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. When you buyLHQW from us, actsmarket.com will donate the same number of boxes to needy seniors above 50 years old, living in 1-room or 2-room rental flats in Singapore, cap at 140 bundles or 700 boxes. [4]. Data synthesis reports the intervention effect of the original study by integrating the cohort study. Among the many commonly used TCMs, the most commonly used one is Lian-Hua Qing-Wen Granule (LHQWG). For patients showing mild symptoms, Lianhua Qingwen would be more effective. Biotechnology communication 2003;14:3902. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. Please enable it to take advantage of the complete set of features! [Package]Aluminium-plastic package, 24 capsules/box, [Executive Standard]Chinese Pharmacopoeia 2010, the 2nd supplemental volume. [8]. Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. Stage Food and Drug Administration Approval number:Z20040063. If you buy two boxes at a time, or an integral multiple of two boxes (such as 4 boxes or 6 boxes), we will give you one box for every two boxes. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology[32] will be used to assess the quality of the evidence and risk of bias with on-line GRADE (https://www.gradeworkinggroup.org/). After determining how to combine different types of studies, NRIs use the method of inverse variance of random-effect model to evaluate and calculate the 95% CI of the effect value. As stated in the research paper published on "Scientific World Journal", Lianhua-Qingwen capsule (LQC) is a commonly used Chinese medical preparation to treat virus and especially played a very important role in the fight against severe acute respiratory syndrome (S-A-R-S) in 2002-2003 in China. >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Please abide by Rappler's commenting guidelines. Even Efficacy and safety of herbal medicine (Lianhuaqingwen) for In 2013, Expert Consensus on Medical Treatment for Patients Infected with H7N9 Avian Influenza (2013), issued by the National Health and Family Planning Commission This product is capsule, brown to yellowish brown particles and powder inside;smell slightly fragrant, slightly bitter taste. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. FDA Director General Eric Domingo likewise confirmed the approval of Lianhua Qingwen in a text message to Rappler on Wednesday afternoon. http://creativecommons.org/licenses/by/4.0. Dosage: 2 capsules twice a day ( after breakfast & dinner). AChinese researchclaimsthat ithas been used for viral infections for more than a decade, includingSevere Acute Respiratory Syndrome (SARS)in 20022003. The authors have no conflicts of interest to disclose. It contains 13 herbs that are anti-viral and anti-inflammatory. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as part of its standard coronavirus treatments. Chinese Journal of experimental pharmacology 2015;21:13943. 11. 1. The results will be cross-checked by the 2 reviewers, and any disagreements will be resolved by consensus, with any ongoing differences in opinion being arbitrated by a third reviewer (LMJ). [14]. For oral administration, 4 capsules once, 3 times a day. The DDB, however, had no objections to the product registration ofLHQWwith the Philippine FDA and said that the importer or distributor shall secure the proper license from thePhilippine Drug Enforcement Agency (PDEA) and comply with all regulatory requirements and relevant issuances. [27]. FREE SHIPPING within SG when you buy 4 boxes or more. Efficacy and safety of Lianhua Qingwen in the treatment Measuring inconsistency in meta-analyses. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The course of treatment is 7-10 days for patients with mild and moderate COVID-19. STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. Ends on 31 July 2022. Some notable dangerous reactions include heart attacks, strokes, seizures, and sudden deaths. Sign in to listen to groundbreaking journalism. Select all eligible studies published before May 8, 2020. Select all eligible studies published before May 8, 2020. Hongying Mo, Zifeng Yang, Jinping Zheng, et al. Led by Iloilos most respected journalists, the Daily Guardian pledges to tell the Ilonggo story as seen through the various lenses of society so that every side may be told. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by the national Wei Jian administration and the State Administration of traditional Chinese medicine for 20 times. Lianhua Qingwen was developed by Shijiazhuang Yiling Pharmaceutical in 2003 as a treatment for severe acute respiratory syndrome (SARS) following the outbreak of the disease in 2002 and was listed by the National Health Commission of China in 2004 as a treatment for influenza and other respiratory disease. Children should be administered under adults supervision. She can be reached atbandiolateresamayb@gmail.com. FDA Phase-II Clinical Study, In 2020, Diagnosis and Treatment Scheme for Novel Coronavirus Pneumonia, jointly issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine MJL will arbitrate any disagreement and ensure that no errors occur during the review. J Integr Med. [36]. However, this systematic review will have some limitations. 94d329df351d7da8aefc2.shtml, https: //www.who.int/docs/default source/coronaviruse/situation-reports/20200325-sitrep-65-, https://www.jiyinzaixian.com/news/bNu5eb13ba6806e0, http://www.xinhuanet.com/politics/2020-03/24/c_1125757251.htm, http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml. System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. The composition of Lianhua Qingwen granules is consistent with the pathogenesis of the disease. WebTo evaluate the efficacy and safety of Lianhua Qingwen capsule for influenza. It includes forsythia, honeysuckle, ephedra (ma huang), armeniacae, gypsum, isatis, dryopteridis, houttuynia, pogostemon, rheum, rhodiola, Chinese peppermint (bohe), and liquorice. A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. Objective: | 2023 ACTSmarket, capsules x 3 times a day ( after breakfast, lunch and dinner. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. The findings of the trial showed strong indications of LHQW in helping patients recover faster and in the prevention of severe covid disease, when compared to the control group using only standard treatment. sharing sensitive information, make sure youre on a federal This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. Post code: 050035 Tel: 0086-311-85901643 Fax: 0086-311-85906730 Website: http://www.yiling.cn Any questions or problems, please do not hesitate to contact manufacturer. A: CT at admission (February 14, 2020); B: CT Reexamination after treatment (February 25, 2020); C: CT Reexamination after treatment (March 13, 2020); D: CT Reexamination after discharge (June 11, 2020). Xiaoyan Liu. In 2018, Diagnosis and Treatment Scheme for Influenza (2018), issued by the National Health and Family Planning Commission Here are links to the publications that published the results of the clinical trial :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229744/https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtmlIngredients & ContradicationsPlease refer to the pictures for more informationUSAGE FOR RESPIRATORY DISEASES SUCH AS FLUS AND COLDSProphylaxis: If you know you are going out, take LHQW the day before, the day of the outing and the day after the outing. Domingo said this version of the capsule was still unregistered to date, meaning the FDA could not guarantee its quality and safety. The full text of articles potentially suitable for the review will be obtained for further assessing eligibility based on the inclusion criteria or/and exclusion criteria. The Chinese embassy likewise advised the public to only purchase and consume authentic traditional Chinese medicine produced by qualified pharmaceutical manufacturers. If I2 test 50%, a random-effects model will be used for data analysis instead. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. In 2005, Diagnosis and Treatment Scheme for Patients Infected with Avian Influenza (2005), issued by the Ministry of Health, Famous Kazakhstan journalist talks about Lianhua, New Progress in Study on Mechanism of Lianhua Qingwen Capsules for Treatment of COVID-19, TCM (Traditional Chinese Medicine) received by Cambodia for treating COVID-19 patients. - China reported 11 new infections of the coronavirus on March 14, and for the first time since the start of the epidemic the majority of them were imported cases from overseas. LHQW won the 2nd prize of the National Scientific and Technological Progress Award in 2011 for the treatment of influenza. Food and Drug Administration Evid Based Complement Alternat Med. Some error has occurred while processing your request. Unable to load your collection due to an error, Unable to load your delegates due to an error. The FDA had earlier put out an advisory in May warning against the purchase of unregistered versions of the Lianhua Qingwen Jiaonang capsule which had different labels. Lianhua Qingwen For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. Wenwen Cui, Xin Jin, Yanfen Zhang, et al. Get new journal Tables of Contents sent right to your email inbox, http://creativecommons.org/licenses/by/4.0, Http://www.nhc.gov.cn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386.sht-ml, https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-, http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd. Excluded from the meta-analysis are duplicated publications; the control group also used traditional Chinese medicine intervention, studies with unavailable or incorrect data, articles not reporting outcomes of interest. Please try again soon. A: Chest radiograph of normal people; B: Chest radiograph of a. [31]. SHI JIA ZHUANG YI LING PHARMACEUTICAL CO.,LTD. WebDosage/Direction for Use 4 cap tid w/ warm water. Lianhua Qingwen Capsule - Yiling Consult with doctors or pharmacists before administration if other medicines are received during this time. It has important clinical significance for alleviating the severity of COVID-19 and shortening the course of disease. Experimental study on the anti Coxsackie B4 virus effect of Lianhuaqingwen capsule [J]. 8.Three days without any remission,or symptems aggravated,appeared new serious symptems, should go to hospital. As a drug, ephedrine is a decongestant and bronchodilator. For RCTs, the Cochrane Collaboration's tool for assessing risk of bias will be used; 2. Highlight selected keywords in the article text. It has a history of abuse by athletes due to its ability to increase energy and alertness and help weight loss. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. Use left/right arrows to navigate the slideshow or swipe left/right if using a mobile device. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. Children, pregnant women, nursing mother, senile and infirm patients or those with week spleen should take medicine under doctors direction. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Biotechnology communication 2003;14:3902. Also excluded are studies enrolling <30 participants. Common side effects are heart palpitations, nausea, and vomiting. [33].
lianhua qingwen dosage